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Article

Uroporphyria in the Cyp1a2-/- mouse.

Blood cells, molecules & diseases - 15 Dec 2011

Phillips John D, Kushner James P, Bergonia Hector A, Franklin Michael R

Abstract excerpt

Cytochrome P4501A2 (Cyp1a2) is important in the development of uroporphyria in mice, a model of porphyria cutanea tarda in humans. Heretofore, mice homozygous for the Cyp1a2-/- mutation do not develop uroporphyria with treatment regimens that result in uroporphyria in wild-type mice. Here we report uroporphyria development in Cyp1a2-/- mice additionally null for both alleles of the hemochromatosis (Hfe) gene and...

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Identifiers

PMID: 21880518
DOI: 10.1016/j.bcmd.2011.07.006
PMCID: PMC3223295

Genes

UROD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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