Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification.

Journal of Alzheimer's disease : JAD - 1 Jul 2006

Ohta Shigeo, Ohsawa Ikuroh

Abstract excerpt

The mitochondrion is an organelle that plays a central role in energy production. It, at the same time, generates reactive oxygen species as by-products. Large-scale epidemiological case-control studies suggest the involvements of dihydrolipoamide succinyltransferase (DLST) of the mitochondrial Krebs cycle and mitochondrial aldehyde dehydrogenase-2 (ALDH2) in Alzheimer's disease (AD). The DLST gene has two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Dehydrogenase
Share to Aldehyde Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aldehydes

Share to Amyloid beta-Peptides

Share to Electron Transport Complex IV

Share to Mitochondria

Share to Mitochondrial Diseases

Share to Oxidative Stress

Source

Identifiers

PMID: 16873963
DOI: 10.3233/jad-2006-9208

Genes

ALDH2
DLST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification.PMID 16873963Read ↗

The role of mitochondrial defects and oxidative stress in Alzheimer’s diseaseSemantic proximity Read ↗

Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease: Insights into Pathophysiology and TreatmentSemantic proximity Read ↗

Mitochondrial dysfunction and Alzheimer's diseaseSemantic proximity Read ↗

Mitochondrial Disorders in Alzheimer’s DiseaseSemantic proximity Read ↗

Peripheral Mitochondrial Dysfunction: A Potential Contributor to the Development of Metabolic Disorders and Alzheimer’s DiseaseSemantic proximity Read ↗

Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.Semantic proximity Read ↗

Etiology of type 2 diabetes and Alzheimer's disease: Exploring the mitochondriaSemantic proximity Read ↗

Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s diseaseSemantic proximity Read ↗

Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer’s DiseaseSemantic proximity Read ↗

Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and InsulinSemantic proximity Read ↗

Clinical features and pathogenesis of Alzheimer's disease: involvement of mitochondria and mitochondrial DNA.Semantic proximity Read ↗

Contributions of mitochondrial alterations, resulting from bad genes and a hostile environment, to the pathogenesis of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.