Article
Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Feb 2011
Yao Jun, Du Heng, Yan Shiqiang, Fang Fang, Wang Chaodong, Lue Lih-Fen, Guo Lan, Chen Doris, Stern David M, Gunn Moore Frank J, Xi Chen John, Arancio Ottavio, Yan Shirley ShiDu
Abstract excerpt
Amyloid-β (Aβ) peptide-binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, exacerbates Aβ-induced cell stress. The interaction of ABAD with Aβ exacerbates Aβ-induced mitochondrial and neuronal dysfunction. Here, we show that inhibition of the ABAD-Aβ interaction, usi...
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