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Article

ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2005

Takuma Kazuhiro, Yao Jun, Huang Jianmin, Xu Hongwei, Chen Xi, Luddy John, Trillat Anne-Cecile, Stern David M, Arancio Ottavio, Yan Shirley Shidu

Abstract excerpt

Amyloid-beta peptide (Abeta) binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, is a cofactor facilitating Abeta-induced cell stress. We hypothesized that ABAD provides a direct link between Abeta and cytotoxicity via mitochondrial oxidant stress. Neurons cultured from transgenic (Tg) mice with targeted overexpression of a mutant form of amyloid precursor protein and ABAD (Tg...

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PMID: 15665036
DOI: 10.1096/fj.04-2582fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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