Article
Genetic variants in the CCR gene cluster and spontaneous viral elimination in hepatitis C-infected patients.
Clinical and experimental immunology - 1 May 2004
Mascheretti S, Hinrichsen H, Ross S, Buggisch P, Hampe J, Foelsch U R, Schreiber S
Abstract excerpt
Hepatitis C virus (HCV) infection results in chronic hepatitis in more than 80% of infected patients while 10-20% of patients recover spontaneously. Host genetic factors may influence the ability to clear the virus after infection. Six single nucleotide polymorphisms and a 32 bp deletion in the genes coding for CCR3, CCR2 and CCR5 (which are all located in a cluster on chromosome 3) were investigated in 465...
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