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Article

Triplet repeat expansion generated by DNA slippage is suppressed by human flap endonuclease 1.

The Journal of biological chemistry - 28 May 2004

Ruggiero Bethany L, Topal Michael D

Abstract excerpt

Human flap endonuclease 1 (h-FEN1) mutations have dramatic effects on repeat instability. Current models for repeat expansion predict that h-FEN1 protein prevents mutations by removing 5'-flaps generated at ends of Okazaki fragments by strand displacement synthesis. The models propose that hairpi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15037629
DOI: 10.1074/jbc.M313170200

Genes

FEN1
GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15037629-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Triplet repeat expansion generated by DNA slippage is suppressed by human flap endonuclease 1.PMID 15037629Read ↗

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