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Article

GIT1 is a scaffold for ERK1/2 activation in focal adhesions.

The Journal of biological chemistry - 29 Jul 2005

Yin Guoyong, Zheng Qinlei, Yan Chen, Berk Bradford C

Abstract excerpt

GIT1 (G protein-coupled receptor kinase-interacting protein 1) has been shown to regulate focal adhesion disassembly. We previously reported that GIT1 associates with MEK1 and acts as a scaffold to enhance ERK1/2 activation. Here, we show that GIT1 co-localizes with ERK1/2 in focal adhesions and regulates cell migration in vascular smooth muscle cells, HEK293 cells, and HeLa cells. Immunofluorescence showed that...

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Source

Identifiers

PMID: 15923189
DOI: 10.1074/jbc.M502271200

Genes

GIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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