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Article

Evolution of the human immunodeficiency virus envelope gene is dominated by purifying selection.

Genetics - 1 Nov 2006

Edwards C T T, Holmes E C, Pybus O G, Wilson D J, Viscidi R P, Abrams E J, Phillips R E, Drummond A J

Abstract excerpt

The evolution of the human immunodeficiency virus (HIV-1) during chronic infection involves the rapid, continuous turnover of genetic diversity. However, the role of natural selection, relative to random genetic drift, in governing this process is unclear. We tested a stochastic model of genetic drift using partial envelope sequences sampled longitudinally in 28 infected children. In each case the Bayesian...

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Identifiers

PMID: 16951087
DOI: 10.1534/genetics.105.052019
PMCID: PMC1667091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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