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Article

Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice.

Experimental neurology - 1 May 2004

Schilling Gabriele, Savonenko Alena V, Coonfield Michael L, Morton Johanna L, Vorovich Esther, Gale Alexa, Neslon Christopher, Chan Ning, Eaton Michelle, Fromholt David, Ross Christopher A, Borchelt David R

Abstract excerpt

The HD-N171-82Q (line 81) mouse model of Huntington's disease (HD), expresses an N-terminal fragment of mutant huntingtin (htt), loses motor function, displays HD-related pathological features, and dies prematurely. In the present study, we compare the efficacy with which environmental, pharmacological, and genetic interventions ameliorate these abnormalities. As previously reported for the R6/2 mouse model of...

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Identifiers

PMID: 15081595
DOI: 10.1016/j.expneurol.2004.01.003

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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