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Article

Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease.

Redox biology - 1 Jan 2015

Berggren Kiersten L, Chen Jianfang, Fox Julia, Miller Jonathan, Dodds Lindsay, Dugas Bryan, Vargas Liset, Lothian Amber, McAllum Erin, Volitakis Irene, Roberts Blaine, Bush Ashley I, Fox Jonathan H

Abstract excerpt

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion that encodes a polyglutamine tract in huntingtin (htt) protein. Dysregulation of brain iron homeostasis, oxidative stress and neurodegeneration are consistent features of the HD phenotype. There...

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Identifiers

PMID: 25703232
DOI: 10.1016/j.redox.2015.02.002
PMCID: PMC4348428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25703232-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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