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Article

Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Dumont Magali, Kipiani Khatuna, Yu Fangmin, Wille Elizabeth, Katz Maya, Calingasan Noel Y, Gouras Gunnar K, Lin Michael T, Beal M Flint

Abstract excerpt

Increased oxidative stress is implicated in the pathogenesis of Alzheimer's disease (AD). A large body of evidence suggests that mitochondrial dysfunction and increased reactive oxygen species occur prior to amyloid-β (Aβ) deposition. Coenzyme Q10 (CoQ10), a component of the mitochondrial electron transport chain, is well characterized as a neuroprotective antioxidant in animal models and human trials of...

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Identifiers

PMID: 21799249
DOI: 10.3233/JAD-2011-110209
PMCID: PMC3267988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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