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Article

Accurate sequencing by hybridization for DNA diagnostics and individual genomics.

Nature biotechnology - 1 Jan 1998

Drmanac S, Kita D, Labat I, Hauser B, Schmidt C, Burczak J D, Drmanac R

Abstract excerpt

Medical DNA diagnostics will increasingly rely on an accurate and inexpensive identification of mutations that affect the function of a gene. To validate diagnostic sequencing by hybridization (SBH), a number of p53 samples were analyzed with the complete set of 8192 noncomplementary 7-mer oligonucleotides. In four repeated, blind experiments we accurately sequenced 1.1 kb per each of 12 homozygote and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 9447594
DOI: 10.1038/nbt0198-54

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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