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Article

Accurate sequencing by hybridization for DNA diagnostics and individual genomics.

Nature biotechnology - 1 Jan 1998

Drmanac S, Kita D, Labat I, Hauser B, Schmidt C, Burczak J D, Drmanac R

Abstract excerpt

Medical DNA diagnostics will increasingly rely on an accurate and inexpensive identification of mutations that affect the function of a gene. To validate diagnostic sequencing by hybridization (SBH), a number of p53 samples were analyzed with the complete set of 8192 noncomplementary 7-mer oligon...

Topics

DNA
DNA Primers
Exons
Genes, p53
Genome, Human
Genotype
Humans
Mutation
Nucleic Acid Hybridization
Oligonucleotide Probes
Reproducibility of Results
Sequence Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9447594
DOI: 10.1038/nbt0198-54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9447594-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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