Article
Sensitive detection of p53 mutation: analysis by direct sequencing and multisequence analysis.
Cancer detection and prevention - 1 Jan 2001
Rozemuller E H, Kropveld A, Kreyveld E, Leppers F G, Scheidel K C, Slootweg P J, Tilanus M G
Abstract excerpt
In a wide variety of tumors, p53 mutations may have prognostic and diagnostic value. However, mutational screening methods often are restricted to the core domain and, therefore, do not detect all mutations. We improved existing sequencing-based mutation analysis methods consisting of direct sequencing of all exons of the p53 gene and RNA. Multisequence analysis software was developed and applied to increase the...
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