Article
Detection and assignment of TP53 mutations in tumor DNA using peptide mass signature genotyping.
Human mutation - 1 Aug 2003
Telmer Cheryl A, An Jiyan, Malehorn David E, Zeng Xuemei, Gollin Susanne M, Ishwad Chandramohan S, Jarvik Jonathan W
Abstract excerpt
This report describes the application of a new approach to tumor genotyping called peptide mass signature genotyping (PMSG) that is particularly suited to detecting minority sequences in a DNA sample. Detecting minority sequences is essential for accurate tumor genotyping because tumor resections are generally a mixture of malignant and non-malignant cells, with the mutations of interest often outnumbered by the...
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