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Article

Solid phase capturable dideoxynucleotides for multiplex genotyping using mass spectrometry.

Nucleic acids research - 15 Aug 2002

Kim Sobin, Edwards John R, Deng Liyong, Chung Wendy, Ju Jingyue

Abstract excerpt

We report an approach using solid phase capturable biotinylated dideoxynucleotides (biotin-ddNTPs) in single base extension for multiplex genotyping by mass spectrometry (MS). In this method, oligonucleotide primers that have different molecular weights and that are specific to the polymorphic sites in the DNA template are extended with biotin-ddNTPs by DNA polymerase to generate 3'-biotinylated DNA products....

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Identifiers

PMID: 12177313
DOI: 10.1093/nar/gnf084
PMCID: PMC134258

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