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Article

Multiplex single-nucleotide polymorphism genotyping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Analytical biochemistry - 1 Mar 2003

Yang Heyi, Wang Haijian, Wang Jie, Cai Yun, Zhou Gangqiao, He FuChu, Qian Xiaohong

Abstract excerpt

A robust high-throughput single-nucleotide polymorphism (SNP) genotyping method is reported, which applies allele-specific extension to achieve allelic discrimination and uses matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to measure the natural molecular weight difference of oligonucleotides for determination of the base in a single-nucleotide polymorphic location. Tenfold PCR is...

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PMID: 12633602
DOI: 10.1016/s0003-2697(02)00641-3

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