Article
A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis.
The Journal of biological chemistry - 7 Sept 2001
Stenmark P, Grünler J, Mattsson J, Sindelar P J, Nordlund P, Berthold D A
Abstract excerpt
Ubiquinone (UQ) is an essential cofactor for respiratory metabolism. In yeast, mutation of the COQ7 gene results in the absence of UQ biosynthesis and demonstrates a role for this gene in the step leading to the hydroxylation of 5-demethoxyubiquinone. Intriguingly, the disruption of the corresponding gene in Caenorhabditis elegans, clk-1, results in a prolonged life span and a slowing of development. Because of...
Topics
- Amino Acid Sequence
- Binding Sites
- Caenorhabditis elegans Proteins
- Cell Membrane
- Cloning, Molecular
- Escherichia coli
- Iron
- Mixed Function Oxygenases
- Models, Chemical
- Models, Molecular