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Article

Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.

Oncogene - 24 Jun 2004

Fernandez Paloma, Carretero Julian, Medina Pedro P, Jimenez Ana I, Rodriguez-Perales Sandra, Paz Maria F, Cigudosa Juan C, Esteller Manel, Lombardia Luis, Morente Manuel, Sanchez-Verde Lydia, Sotelo Teresa, Sanchez-Cespedes Montserrat

Abstract excerpt

LKB1, a tumor-suppressor gene that codifies for a serine/threonine kinase, is mutated in the germ-line of patients affected with the Peutz-Jeghers syndrome (PJS), which have an increased incidence of several cancers including gastrointestinal, pancreatic and lung carcinomas. Regarding tumors arising in non-PJS patients, we recently observed that at least one-third of lung adenocarcinomas (LADs) harbor somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15077168
DOI: 10.1038/sj.onc.1207665

Genes

AMPD3
MEIS2
APRT
ATF5
MPP1
ROCK2
USP16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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