Article
LKB1 mutation in large cell carcinoma of the lung.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2006
Zhong Diansheng, Guo Lizheng, de Aguirre Itziar, Liu Xiuju, Lamb Neil, Sun Shi-Yong, Gal Anthony A, Vertino Paula M, Zhou Wei
Abstract excerpt
Germline inactivation of LKB1 is responsible for Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by benign hamartomas of the GI tract and an increased predisposition to certain cancers, including lung. Acquired mutations in LKB1 are rarely observed in most sporadic tumor types except for adenocarcinomas of the lung where up to 50% harbor inactivating mutations. In this study, we focused on...
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