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Article

Reduced HGF expression in subcutaneous CT26 tumor genetically modified to secrete NK4 and its possible relation with antitumor effects.

Cancer science - 1 Apr 2004

Kubota Takeshi, Fujiwara Hitoshi, Amaike Hisashi, Takashima Kazuhiro, Inada Satoshi, Atsuji Kiyoto, Yoshimura Mamoru, Matsumoto Kunio, Nakamura Toshikazu, Yamagishi Hisakazu

Abstract excerpt

Tumor-stromal interactions, which are regulated by stromal-derived HGF and tumor-derived HGF inducers, are essential for tumor cell acquisition of such malignant properties as invasion and metastasis. NK4, a proteolytic cleavage product of HGF, has antitumor activities as both an HGF antagonist and an angiogenesis inhibitor. In this study, we examined the in vitro and in vivo behaviors of mouse colon...

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Source

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Identifiers

PMID: 15072590
DOI: 10.1111/j.1349-7006.2004.tb03210.x
PMCID: PMC11158525

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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