Identification of a novel variant hepatocyte growth factor secreted by spleen-derived stromal cells.

doi:10.1006/bbrc.1996.0921

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Article

Identification of a novel variant hepatocyte growth factor secreted by spleen-derived stromal cells.

Biochemical and biophysical research communications - 25 Jun 1996

Miau L H, Jan Y W, Shen B J, Tsai W H, Lee H S, Lee S C

Abstract excerpt

Stromal cells can interact with parenchymal cells by secreting various cytokines to affect the growth, differentiation or movement of the latter. Here we report the identification and characterization of a novel variant hepatocyte growth factor (HGF) from the conditioned medium of stromal cells derived from mouse spleen. Compared to human HGF, it has much lower heparin-binding activity and lacks the beta-chain....

Topics

Animals
Antibodies
Cell Division
Cell Line
Chromatography, Affinity
Genetic Variation
Heparin
Hepatocyte Growth Factor
Humans
Liver
Liver Neoplasms, Experimental
Mice
Rats
Recombinant Proteins
Spleen
Stromal Cells
Tumor Cells, Cultured

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PMID: 8687422
DOI: 10.1006/bbrc.1996.0921

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