Article
Influence of hepatocyte growth factor/scatter factor on the metastatic phenotype of B16 melanoma cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 1998
Rusciano D, Lin S, Lorenzoni P, Casella N, Burger M M
Abstract excerpt
B16 melanoma cells selected in mice for liver-specific metastasis (B16-LS9) overexpress a constitutively active form of the hepatocyte growth factor/scatter factor receptor (HGF/SFr), the product of the c-met proto-oncogene. HGF/SF can affect both invasion and growth of receptive cells. In fact, we show that overexpression of c-met in B16-LS9 cells results in a higher inducibility of two different proteolytic...
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