Article
Influence of hepatocyte growth factor/scatter factor on the metastatic phenotype of B16 melanoma cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 1998
Rusciano D, Lin S, Lorenzoni P, Casella N, Burger M M
Abstract excerpt
B16 melanoma cells selected in mice for liver-specific metastasis (B16-LS9) overexpress a constitutively active form of the hepatocyte growth factor/scatter factor receptor (HGF/SFr), the product of the c-met proto-oncogene. HGF/SF can affect both invasion and growth of receptive cells. In fact,...
Topics
- Animals
- Cell Division
- Collagenases
- Enzyme Activation
- Hepatocyte Growth Factor
- Liver Neoplasms, Experimental
- Lung
- Matrix Metalloproteinase 9
- Melanoma, Experimental
- Mice
- Mice, Inbred C57BL
- Phenotype
- Proto-Oncogene Proteins c-met
- Recombinant Proteins
- Tumor Cells, Cultured
- Up-Regulation
- Urokinase-Type Plasminogen Activator