Article
HGF/c-Met overexpressions, but not met mutation, correlates with progression of non-small cell lung cancer.
Pathology oncology research : POR - 1 Apr 2012
Gumustekin Mukaddes, Kargi Aydanur, Bulut Gulay, Gozukizil Aysim, Ulukus Cagnur, Oztop Ilhan, Atabey Nese
Abstract excerpt
Hepatocyte Growth Factor (HGF) and its receptor c-Met are suggested to play an important role in progression of solid organ tumors by mediating cell motility, invasion and metastasis. Overexpression of HGF and c-Met have been shown in non-small-cell lung cancer (NSCLC). However, their role in tumor progression is not clearly defined. The aim of this study is to determine the role of HGF/c-Met pathway and its...
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