Article
CD26 expression determines lung metastasis in mutant F344 rats: involvement of NK cell function and soluble CD26.
Cancer immunology, immunotherapy : CII - 1 Sept 2003
Shingu Kiyoshi, Helfritz Andreas, Zielinska-Skowronek Margot, Meyer-Olson Dirk, Jacobs Roland, Schmidt Reinhold E, Mentlein Rolf, Pabst Reinhard, von Hörsten Stephan
Abstract excerpt
The association between CD26 expression, tumor cell adhesion, metastasis, and natural killer (NK) cell function was investigated in a CD26 mutant Fischer 344 (F344/DuCrj) substrain from Japanese breeders (F344JAP) in comparison with wild-type F344 substrains from US (F344/Crl) and Hannover (HAN; F344/Ztm) breeders. F344JAP rats lack the dipeptidyl peptidase IV activity of CD26 and show a reduced cell surface...
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