Article
Heterogeneity of Stop Codon Readthrough in Single Bacterial Cells and Implications for Population Fitness.
Molecular cell - 7 Sept 2017
Fan Yongqiang, Evans Christopher R, Barber Karl W, Banerjee Kinshuk, Weiss Kalyn J, Margolin William, Igoshin Oleg A, Rinehart Jesse, Ling Jiqiang
Abstract excerpt
Gene expression noise (heterogeneity) leads to phenotypic diversity among isogenic individual cells. Our current understanding of gene expression noise is mostly limited to transcription, as separating translational noise from transcriptional noise has been challenging. It also remains unclear how translational heterogeneity originates. Using a transcription-normalized reporter system, we discovered that stop...
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