Article
Imposition of crossover interference through the nonrandom distribution of synapsis initiation complexes.
Cell - 19 Mar 2004
Fung Jennifer C, Rockmill Beth, Odell Michael, Roeder G Shirleen
Abstract excerpt
Meiotic crossovers (COs) are nonrandomly distributed along chromosomes such that two COs seldom occur close together, a phenomenon known as CO interference. We have used genetic and cytological methods to investigate interference mechanisms in budding yeast. Assembly of the synaptonemal complex (SC) initiates at a few sites along each chromosome, triggered by a complex of proteins (including Zip2 and Zip3) called...
Topics
- Carrier Proteins
- Cells, Cultured
- Chromosome Pairing
- Chromosomes
- Macromolecular Substances
- Meiosis
- Mutation
- Saccharomyces cerevisiae
- Synaptonemal Complex