Article
Downregulation of HLA class II is associated with relapse after allogeneic stem cell transplantation and alters recognition by antigen-specific T cells.
International journal of hematology - 1 Mar 2022
Adachi Yoshitaka, Sakai Toshiyasu, Terakura Seitaro, Shiina Takashi, Suzuki Shingo, Hamana Hiroshi, Kishi Hiroyuki, Sasazuki Takehiko, Arase Hisashi, Hanajiri Ryo, Goto Tatsunori, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi
Abstract excerpt
Genomic deletion of donor-patient-mismatched HLA alleles in leukemic cells is a major cause of relapse after allogeneic hematopoietic stem cell transplantation (HSCT). Mismatched HLA is frequently lost as an individual allele or a whole region in HLA-class I, however, it is downregulated in HLA-class II. We hypothesized that there might be a difference in T cell recognition capacity against epitopes associated...
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