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Natural Killer Cell Alloreactivity for Leukemia Therapy

18 Apr 2005

Abstract excerpt

Donor-versus-recipient natural killer (NK) cell alloreactivity derives from a mismatch between donor NK clones, carrying specific inhibitory receptors for self MHC class I molecules, and MHC class I ligands on recipient cells. When faced with mismatched allogeneic targets, these donor NK clones sense the missing expression of self HLA class I alleles and mediate alloreactions. Transplantation from NK alloreactive...

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PMID: 15838373
DOI: 10.1097/01.cji.0000161395.88959.1f

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