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Article

Population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patients.

Clinical pharmacology and therapeutics - 1 Mar 2003

Takahashi Harumi, Wilkinson Grant R, Caraco Yoseph, Muszkat Mordechai, Kim Richard B, Kashima Toshitaka, Kimura Sosuke, Echizen Hirotoshi

Abstract excerpt

OBJECTIVE: Our objective was to investigate population differences in the metabolic activity of cytochrome P450 (CYP) 2C9 between genotypically matched Caucasian and Japanese patients by using the unbound oral clearance of S-warfarin as an in vivo phenotypic trait measure. METHODS: Ninety Japanese and 47 Caucasian patients receiving maintenance warfarin therapy were studied. Steady-state plasma unbound...

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Source

Identifiers

PMID: 12621390
DOI: 10.1067/mcp.2003.26a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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