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Article

Glucose Regulation of Insulin Gene Transcription and Pre-mRNA Processing in Human Islets

27 Feb 2007

Abstract excerpt

Glucose is the primary regulator of insulin granule release from pancreatic islets. In rodent islets, the role of glucose in the acute regulation of insulin gene transcription has remained unclear, primarily because the abundance and long half-life of insulin mRNA confounds analysis of transcription by traditional methods that measure steady-state mRNA levels. To investigate the nature of glucose-regulated...

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Identifiers

PMID: 17327454
DOI: 10.2337/db06-1440

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