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Selection of HLA-B57-associated Gag A146P mutant by HLA-B∗48:01-restricted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese.

Microbes and infection - 1 Aug 2011

Naruto Takuya, Murakoshi Hayato, Chikata Takayuki, Koyanagi Madoka, Kawashima Yuka, Gatanaga Hiroyuki, Oka Shinichi, Takiguchi Masafumi

Abstract excerpt

We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138-147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140-147(GI8) to be the optimal epitope rather than LI10 and that GI8-specific T cells failed to recognize the A146P mutant virus-infected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21473930
DOI: 10.1016/j.micinf.2011.03.009

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