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Article

Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants.

Antimicrobial agents and chemotherapy - 1 Feb 2005

Freiberg C, Fischer H P, Brunner N A

Abstract excerpt

We present a new strategy for predicting novel antibiotic mechanisms of action based on the analysis of whole-genome microarray data. We first built up a reference compendium of Bacillus subtilis expression profiles induced by 14 different antibiotics. This data set was expanded by adding expression profiles from mutants that showed downregulation of genes coding for proven or emerging antibacterial targets....

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Identifiers

PMID: 15673760
DOI: 10.1128/AAC.49.2.749-759.2005
PMCID: PMC547252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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