Article
TP73 alterations in cervical carcinoma.
Cancer genetics and cytogenetics - 15 Apr 2004
Craveiro Rogéria, Costa Sandra, Pinto Daniela, Salgado Lurdes, Carvalho Luisa, Castro Carla, Bravo Isabel, Lopes Carlos, Silva Isabel, Medeiros Rui
Abstract excerpt
Infection with human papillomaviruses (HPV) is essential in the carcinogenesis of the uterine cervix. However, a complex interrelation between viral and cellular genes is necessary for cell-cycle control deregulation and development and progression of cervical cancer induction. The TP73 gene is localized in 1p36.3 band, which is often deleted by loss of heterozygosity (LOH) in human cancers. We analyzed the p73...
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