Article
Reduced rate of human papillomavirus infection and genetic overtransmission of TP53 72C polymorphic variant lower cervical cancer incidence.
Cancer - 1 Jul 2017
Alsbeih Ghazi A, Al-Harbi Najla M, Bin Judia Sara S, Khoja Hatim A, Shoukri Mohamed M, Tulbah Asma M
Abstract excerpt
BACKGROUND: Cervical cancer is a predominantly human papillomavirus (HPV)-driven disease worldwide. However, its incidence is unexplainably low in western Asia, including Saudi Arabia. Using this paradigm, we investigated the role of HPV infection rate and host genetic predisposition in TP53 G72C single nucleotide polymorphism (SNP) presumed to affect cancer incidence. METHODS: Patients treated between 1990 and...
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