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Article

The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks.

DNA repair - 2 Nov 2004

Lavin Martin F

Abstract excerpt

Mutations in components of the Mre11/Rad50/Nbs1 complex give rise to genetic disorders characterized by neurological abnormalities, radiosensitivity, cell cycle checkpoint defects, genomic instability and cancer predisposition. Evidence exists that this complex associates with chromatin during DNA replication and acts as a sensor of double strand breaks (dsbs) in DNA after exposure to radiation. A series of...

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Identifiers

PMID: 15380107
DOI: 10.1016/j.dnarep.2004.07.001

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks.PMID 15380107Read ↗

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