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Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response.

The FEBS journal - 1 Apr 2006

Lee Joo-Hyeon, Lim Dae-Sik

Abstract excerpt

The Nbs1 protein associates with Mre11 and Rad50 proteins to form the Mre11-Rad50-Nbs1 complex, which plays an important role in the intracellular signaling pathway activated in response to DNA damage. Mutations in the genes for each of these three components of the Mre11-Rad50-Nbs1 complex result in human diseases characterized by genomic instability. Insight into the functions of Nbs1 in the DNA damage response...

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Ataxia Telangiectasia Mutated Proteins
Cell Cycle Proteins
DNA Damage
DNA Repair
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Protein Serine-Threonine Kinases

Tumor Suppressor Proteins

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Identifiers

PMID: 16623700
DOI: 10.1111/j.1742-4658.2006.05191.x

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