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Article

Competition between NBS1 and ATMIN Controls ATM Signaling Pathway Choice

1 Dec 2012

Abstract excerpt

Ataxia telangiectasia mutated (ATM) protein kinase activation by DNA double-strand breaks (DSBs) requires the Mre11-Rad50-NBS1 (MRN) complex, whereas ATM interactor (ATMIN) protein is required for ATM signaling induced by changes in chromatin structure. We show here that NBS1 and ATMIN proteins compete for ATM binding and that this mechanism controls ATM function. DSB-induced ATM substrate phosphorylation was...

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Identifiers

PMID: 23219553
DOI: 10.1016/j.celrep.2012.11.002

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