Article
Genesis of ancestral haplotypes: RNA modifications and reverse transcription-mediated polymorphisms.
Human immunology - 1 Mar 2011
Steele Edward J, Williamson Joseph F, Lester Susan, Stewart Brent J, Millman John A, Carnegie Pat, Lindley Robyn A, Pain Geoff N, Dawkins Roger L
Abstract excerpt
Understanding the genesis of the block haplotype structure of the genome is a major challenge. With the completion of the sequencing of the Human Genome and the initiation of the HapMap project the concept that the chromosomes of the mammalian genome are a mosaic, or patchwork, of conserved extended block haplotype sequences is now accepted by the mainstream genomics research community. Ancestral Haplotypes (AHs)...
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