Article
Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening.
Circulation research - 14 May 2004
Palmer Bradley M, Georgakopoulos Dimitrios, Janssen Paul M, Wang Yuan, Alpert Norman R, Belardi Diego F, Harris Samantha P, Moss Richard L, Burgon Patrick G, Seidman Christine E, Seidman J G, Maughan David W, Kass David A
Abstract excerpt
Despite advances in the molecular biology of cardiac myosin binding protein-C (cMyBP-C), little is understood about its precise role in muscle contraction, particularly in the intact heart. We tested the hypothesis that cMyBP-C is central to the time course and magnitude of left ventricular systolic elastance (chamber stiffening), and assessed mechanisms for this influence in intact hearts, trabeculae, and...
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