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Article

The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations.

Blood - 15 Jul 2004

Danckwardt Sven, Gehring Niels H, Neu-Yilik Gabriele, Hundsdoerfer Patrick, Pforsich Margit, Frede Ute, Hentze Matthias W, Kulozik Andreas E

Abstract excerpt

The functional analysis of the common prothrombin 20210 G>A(F2 20210(*)A) mutation has recently revealed gain of function of 3'end processing as a novel genetic mechanism predisposing to human disease. We now show that the physiologic G at the cleavage site at position 20210 is the functionally least efficient nucleotide to support 3'end processing but has evolved to be physiologically optimal. Furthermore, the...

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Identifiers

PMID: 15059842
DOI: 10.1182/blood-2003-08-2894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations.PMID 15059842Read ↗

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