Article
The Silence Speaks, but We Do Not Listen: Synonymous c.1824C>T Gene Variant in the Last Exon of the Prothrombin Gene as a New Prothrombotic Risk Factor.
Clinical chemistry - 1 Feb 2020
Pruner Iva, Farm Maria, Tomic Branko, Gvozdenov Maja, Kovac Mirjana, Miljic Predrag, Soutari Nida Mahmoud Hourani, Antovic Aleksandra, Radojkovic Dragica, Antovic Jovan, Djordjevic Valentina
Abstract excerpt
BACKGROUND: Thrombosis is a major global disease burden with almost 60% of cases related to underlying heredity and most cases still idiopathic. Synonymous single nucleotide polymorphisms (sSNPs) are considered silent and phenotypically neutral. Our previous study revealed a novel synonymous FII c.1824C>T variant as a potential risk factor for pregnancy loss, but it has not yet been associated with thrombotic...
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