Article
The prothrombin 20209 C-->T mutation in Jewish-Moroccan Caucasians: molecular analysis of gain-of-function of 3' end processing.
Journal of thrombosis and haemostasis : JTH - 1 May 2006
Danckwardt S, Hartmann K, Katz B, Hentze M W, Levy Y, Eichele R, Deutsch V, Kulozik A E, Ben-Tal O
Abstract excerpt
BACKGROUND: Mutations of the 3' end mRNA-processing signal of the prothrombin (F2) gene have been reported to cause elevated F2 plasma concentrations, thrombosis, and complications of pregnancy. Whereas the common F2 20210*A mutation is almost exclusively found in Caucasians, the F2 20209*T mutation has been reported in Afro-Americans and Afro-Caribbeans only. PATIENTS AND METHODS: Using LightCycler technology,...
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