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Article

G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3'-end formation.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2004

Ceelie H, Spaargaren-van Riel C C, Bertina R M, Vos H L

Abstract excerpt

BACKGROUND: The prothrombin G20210A mutation is associated with increased plasma prothrombin levels and risk of thrombosis. The mechanism by which this mutation leads to increased prothrombin expression is as yet unclear and still the subject of debate. OBJECTIVES: The aim of this study was to in...

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Identifiers

PMID: 14717975
DOI: 10.1111/j.1538-7836.2003.00493.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14717975-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3'-end formation.PMID 14717975Read ↗

Prothrombin G20210A is a bifunctional gene polymorphism.Semantic proximity Read ↗

The intronic prothrombin 19911A>G polymorphism influences splicing efficiency and modulates effects of the 20210G>A polymorphism on mRNA amount and expression in a stable reporter gene assay system.Semantic proximity Read ↗

The 20210 G → A mutation in the 3′‐untranslated region of the prothrombin gene and the risk for arterial thrombotic diseaseSemantic proximity Read ↗

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.Semantic proximity Read ↗

A proteomic analysis of changes in prothrombin and plasma proteins associated with the G20210A mutation.Semantic proximity Read ↗

The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations.Semantic proximity Read ↗

The relationship between the prothrombin upstream sequence element and the G20210A polymorphism: the influence of a competitive environment for mRNA 3'-end formation.Semantic proximity Read ↗

The prothrombin 20210 G to A variation and thrombosis.Semantic proximity Read ↗

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The heterozygous 20210 G/A prothrombin genotype is associated with early venous thrombosis in inherited thrombophilias and is not increased in frequency in artery disease.Semantic proximity Read ↗

[From gene to disease; risk factors for venous thrombosis: factor V Leiden and prothrombin 20210A].Semantic proximity Read ↗

Prevalence of the G20210A polymorphism in the 3'-untranslated region of the prothrombin gene in different human populations.Semantic proximity Read ↗

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