Article
A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.
Blood - 15 Nov 1996
Poort S R, Rosendaal F R, Reitsma P H, Bertina R M
Abstract excerpt
We have examined the prothrombin gene as a candidate gene for venous thrombosis in selected patients with a documented familial history of venous thrombophilia. All the exons and the 5'- and 3'-UT region of the prothrombin gene were analyzed by polymerase chain reaction and direct sequencing in 2...
Topics
- Alleles
- Chromosomes, Human, Pair 11
- Disease Susceptibility
- Factor V
- Factor V Deficiency
- Female
- Gene Frequency
- Heterozygote
- Humans
- Male
- Netherlands
- Pedigree
- Prevalence
- Prothrombin
- Risk Factors
- Thrombophlebitis