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Article

A proteomic analysis of changes in prothrombin and plasma proteins associated with the G20210A mutation.

Proteomics - 1 Jul 2004

Gelfi Cecilia, Viganò Agnese, Ripamonti Marilena, Wait Robin, Begum Shajna, Biguzzi Eugenia, Castaman Giancarlo, Faioni Elena Maria

Abstract excerpt

The G-->A mutation at position 20210 of the prothrombin gene, localized in the 3'-polyadenylation untranslated region of the mRNA, is a recognized genetic risk factor for venous thromboembolism. The mechanism by which this base change confers an increased risk of thrombosis compared to noncarriers is undefined. Studies on the mRNA suggest enhanced cleavage site recognition and a change in the location of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15221775
DOI: 10.1002/pmic.200300724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A proteomic analysis of changes in prothrombin and plasma proteins associated with the G20210A mutation.PMID 15221775Read ↗

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