Article
Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 1998
Kyrle P A, Mannhalter C, Béguin S, Stümpflen A, Hirschl M, Weltermann A, Stain M, Brenner B, Speiser W, Pabinger I, Lechner K, Eichinger S
Abstract excerpt
A genetic variation in the prothrombin gene, the G-->A transition at nucleotide 20210, is a risk factor for venous thrombosis in heterozygotes and is associated with increased prothrombin activity. The homozygous phenotype and the extent of thrombin generation in heterozygous and homozygous subje...
Topics
- Adult
- Alleles
- DNA
- Female
- Genetic Carrier Screening
- Heterozygote
- Homozygote
- Humans
- Male
- Middle Aged
- Mutation
- Prospective Studies
- Prothrombin
- Thrombin
- Thrombophilia