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Article

Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence.

The American journal of pathology - 1 Jan 2010

Zulehner Gudrun, Mikula Mario, Schneller Doris, van Zijl Franziska, Huber Heidemarie, Sieghart Wolfgang, Grasl-Kraupp Bettina, Waldhör Thomas, Peck-Radosavljevic Markus, Beug Hartmut, Mikulits Wolfgang

Abstract excerpt

Transforming growth factor-beta cooperates with oncogenic Ras to activate nuclear beta-catenin during the epithelial to mesenchymal transition of hepatocytes, a process relevant in the progression of hepatocellular carcinoma (HCC). In this study we investigated the role of beta-catenin in the dif...

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Identifiers

PMID: 20008139
DOI: 10.2353/ajpath.2010.090300
PMCID: PMC2797905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20008139-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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