Article
INK4a-ARF mutations in skin carcinomas from UV irradiated hairless mice.
Molecular carcinogenesis - 1 Apr 2004
Soufir N, Queille S, Mollier K, Roux E, Sarasin A, de Gruijl F R, Fourtanier A M, Daya-Grosjean L, Basset-Seguin N
Abstract excerpt
To characterize further the role of the INK4a-ARF locus in the multistep process of skin carcinogenesis, we performed a mutational analysis of this locus in skin lesions from hairless mice either irradiated with UVB alone or with a solar simulator delivering UVA + B. INK4a-ARF mutations were present in five of 57 squamous cell carcinomas (9%), but no mutation was detected in precancerous lesions. All mutations...
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