Article
p53 Mutations in hairless SKH-hr1 mouse skin tumors induced by a solar simulator.
Photochemistry and photobiology - 1 Feb 1998
Ananthaswamy H N, Fourtanier A, Evans R L, Tison S, Medaisko C, Ullrich S E, Kripke M L
Abstract excerpt
In this study, we investigated whether the spectrum of p53 mutations in skin tumors induced in hairless SKH-hr1 mice by a solar simulator (290-400 nm) are similar to those found in skin tumors induced in C3H mice by UV radiation from unfiltered (250-400 nm) and Kodacel-filtered (290-400 nm) FS40 sunlamps. Analysis of tumor DNA for p53 mutations revealed that 14 of 16 (87.5%) SkH-hr1 skin tumors induced by the...
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