Article
Low incidence of p53 mutations in UVA (365-nm)-induced skin tumors in hairless mice.
Cancer research - 1 Apr 1997
van Kranen H J, de Laat A, van de Ven J, Wester P W, de Vries A, Berg R J, van Kreijl C F, de Gruijl F R
Abstract excerpt
Mutations with clear "UVB fingerprints" have been observed in the p53 gene of human nonmelanoma skin tumors and of experimentally UVB-induced murine skin tumors. Although UVA (315-400 nm) radiation is also a complete carcinogen, its contribution to sunlight-induced mutagenesis remains poorly characterized. There is experimental evidence that the production of reactive oxygen species plays a more dominant role...
Topics
- Animals
- Carcinoma, Squamous Cell
- DNA Mutational Analysis
- Female
- Genes, p53
- Immunohistochemistry
- Male
- Mice
- Mice, Inbred Strains
- Mutation
- Neoplasms, Radiation-Induced
- Papilloma
- Skin Neoplasms
- Ultraviolet Rays